Associations
The primary goal of this study was to analyze urinary Na + , K + and the Na + :K + excretion ratio, for associations with changes in systolic blood pressure (SBP) in participants from the DASH–Sodium trial during the initial screening period in which participants were consuming their regular diet without dietary intervention. The secondary goals of this study were to investigate: (a) the impact of the salt sensitivity of blood pressure on these responses and (b) the impact of the DASH–Sodium dietary intervention, which lowers SBP and increases dietary K + intake, on these potential associations. Our analysis reports that in the DASH–Sodium study cohort: (1) a daily excretion of <1 g K + /day is associated with elevated SBP, (2) urinary K + excretion of >1 g/day does not correlate with a reduction in SBP and, (3) a reduction in the urinary Na + :K + excretion ratio is not associated with lower SBP irrespective of the salt sensitivity of blood pressure. Collectively our data support the recent DRI recommendation not to propose a DRI for K + and suggest that further evidence is required to support the establishment of a Na + /K + excretion ratio that would reduce SBP in the general population.
Logical variables
Mean SBP relative to urinary salt to potassium (Na + /K + ) removal proportion at the time of tests in accordance with weight reduction intervention away from Fat loss Remedies for Stop Blood pressure (DASH) large salt (HS) and you may reduced salt (LS) eating plan inside (a) sodium delicate (letter = 71), (b) sodium resistant (letter = 119) someone, viewpoints found once the suggest ± SD.
Significantly, we observed no association between the urinary Na + :K + ratio and SBP on the DASH HS or DASH LS dietary intervention in either SS (DASH HS R 2 = 0.04, DASH LS R 2 = 0.02) or SR (DASH HS R 2 = 0.04, DASH LS R 2 = 0.00002) participants (Fig. https://datingranking.net/pl/omegle-recenzja/ 5a, b). The DASH dietary intervention significantly increased the number of participants in both SS and SR groups with a urinary Na + :K + ratio of <1 on both the HS and LS diet. However, the urinary Na + :K + had no impact on SBP within dietary intake groups (Fig. 6a, b). Further, when expressed as a frequency distribution histogram the change in SBP from the DASH HS to LS dietary intervention exhibits a profound leftward shift in the SS group compared to SR group (Fig. 7a). In contrast, the frequency distribution histogram for change in the urinary Na + :K + ratio from the DASH HS to LS dietary intervention shows no difference in the Gaussian curve and distribution between SS and SR participants (Fig. 7b).
After that, numerous studies have suggested your blood pressure prevention evoked of the K + consumption could be influenced by fat reduction Na + consumption [twenty eight, 29]. In our research of one’s Dashboard-Sodium dataset i noticed no association with urinary K + excretion and you can SBP, during the patient testing head to or through the Dashboard dietary intervention when Na + intake is actually changed, indicating a liberty of one’s ramifications of Na + and you can K + on SBP inside investigation. The newest 2019 DRI Report figured there was shortage of research toward the effects away from K + with the hypertension and you will failed to establish a beneficial DRI out-of K + . Our research support the 2019 DRI Statement and you may implies that weightloss K + supplements will most likely not significantly remove blood pressure level on general population.
Summation
Stamler J, Flower Grams, Stamler R, Elliott P, Dyer A, Marmot M. INTERSALT research results. Societal health insurance and healthcare effects. Blood pressure level. 1989;–eight.